Article

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

2023-02-24

Abstract excerpt

<h4>Summary</h4> Deficiency for the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) leads to chromosomal instability and diseases such as cancer. Yet, defective HR also results in vulnerabilities that can be exploited for targeted therapy. Here, we identify such a vulnerability and show that BRCA1-deficient cells are dependent on the long-range end-resection factor EXO1 for survival. E...

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Literature Corpus work: c884a75c-67e9-56cb-bbcd-f960913bc452
DOI: 10.1101/2023.02.24.529205

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