Article

The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

2025-07-26

Abstract excerpt

<h4>ABSTRACT</h4> The activating signal co-integrator 1 complex subunit 3 (ASCC3), the largest subunit of ASCC, is one of two Ski2-like helicases with duplicated helicase cassettes encoded by the human genome. ASCC3 has been implicated in transcriptional regulation, alkylation damage repair, and ribosome quality control. In addition, published proteomics studies suggest that ASCC3 is associated with stalled forks...

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Identifiers and source

Literature Corpus work: bec9cd82-b279-57a1-9bca-cfc01b882214
DOI: 10.1101/2025.07.24.666583

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