Article

XPF mediates 3’ flap processing for FEN1-independent Okazaki fragment maturation

2025-10-25

Abstract excerpt

Okazaki fragment maturation (OFM), the process that removes RNA-DNA primers, is a major source of DNA replication stress and mutations. It involves Polδ-mediated DNA strand displacement synthesis that produces 5’ flaps, FEN1-mediated 5’ flap cleavage, and LIG1-catalyzed nick ligation. Recently, we discovered that under stress conditions, yeast cells convert 5’ flaps into 3’ flaps, which are degraded by 3’ flap nuc...

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Literature Corpus work: 5e8c0529-8b5a-50e1-8d35-de850649db09
DOI: 10.1101/2025.10.24.684453

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