Article

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect

2023-10-11

Abstract excerpt

<h4>ABSTRACT</h4> DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. To determine the molecular and genomic impact of a global DDT defect, we studied Pcna K164R/- ;Rev1 -/- compound mutants. Double mutant (DM) cells displayed increased replication stress, hypersensitivity to genotoxic agents, replication speed, and repriming. A whole genome CRISPR-Cas9 screen r...

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Literature Corpus work: f70c547a-7f3b-5b13-9c34-0093a2967f28
DOI: 10.1101/2023.10.11.561854

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