Article

<i>APOE4</i> and <i>INPP5D</i> converge on membrane mechanics to regulate endocytosis in human astrocytes

2026-05-25

Abstract excerpt

Disrupted endocytosis is an early feature of Alzheimer’s disease (AD), but how genetic risk factors functionally impact this pathway remains unclear. Using isogenic human iPSC-derived astrocytes, we show that the AD risk variant, APOE4, impairs clathrin-mediated membrane curvature, clathrin-mediated endocytosis, and alters plasma membrane lipid saturation and tension. Compared to APOE3 astrocytes, APOE4 cells d...

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Literature Corpus work: a0e074e8-065b-5707-a87a-35e38372db04
DOI: 10.64898/2026.05.22.726347

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