Article

INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia

2025-10-27

Abstract excerpt

<h4>ABSTRACT</h4> INPP5D , which encodes SHIP1, is genetically associated with Alzheimer’s disease (AD) risk and regulates microglial immune function. Here we identified SHIP1 as a regulator of endo-lysosomal homeostasis in human microglia. INPP5D haploinsufficiency impaired endosome maturation and lysosomal degradation, leading to lipid droplet accumulation, lysosomal stress, and NLRP3 inflammasome activation....

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Literature Corpus work: bf4ef92b-ecd4-59ab-b271-396106eb86c2
DOI: 10.1101/2025.10.27.684632

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