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PICALM and Alzheimer's Disease: An Update and Perspectives.

Cells - 10 Dec 2022

Ando Kunie, Nagaraj Siranjeevi, Küçükali Fahri, de Fisenne Marie-Ange, Kosa Andreea-Claudia, Doeraene Emilie, Lopez Gutierrez Lidia, Brion Jean-Pierre, Leroy Karelle

Abstract excerpt

Genome-wide association studies (GWAS) have identified the PICALM (Phosphatidylinositol binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus after APOE and BIN1. PICALM is a clathrin-adaptor protein that plays a critical role in clathrin-mediated endocytosis and autophagy. Since the effects of genetic variants of PICALM as AD-susceptibility loci have been confirmed by...

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Identifiers

PMID: 36552756
DOI: 10.3390/cells11243994
PMCID: PMC9776874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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