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Article

Cell type-specific functions of Alzheimer's disease endocytic risk genes

18 Feb 2024

Abstract excerpt

Endocytosis is a key cellular pathway required for the internalization of cellular nutrients, lipids and receptor-bound cargoes. It is also critical for the recycling of cellular components, cellular trafficking and membrane dynamics. The endocytic pathway has been consistently implicated in Alzheimer's disease (AD) through repeated genome-wide association studies and the existence of rare coding mutations in...

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PMID: 38368934
DOI: 10.1098/rstb.2022.0378

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