Article

Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin mediated endocytosis

2021-01-31

Abstract excerpt

<h4>SUMMARY</h4> As the principal internalization mechanism in mammalian cells, clathrin-mediated endocytosis (CME) is critical for cellular signal transduction, receptor recycling, and membrane homeostasis. Acute depletion of cholesterol disrupts CME, motivating analysis of CME dynamics in the context of disrupted cholesterol synthesis, sterol specificity, mechanisms involved, and relevance to disease pathology....

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Literature Corpus work: 91f4d2e1-a209-54a7-b650-03cc1cc92d97
DOI: 10.1101/2021.01.31.428633

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