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Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity

2022-11-21

Abstract excerpt

<h4>Background: </h4> The amyloid precursor protein (APP), a synaptic adhesion molecule, is a key player in Alzheimer`s disease (AD) and the precursor of the Aβ peptide, which is generated by consecutive cleavages of β- and γ-secretases. Familial Alzheimer’s disease (FAD) describes a hereditary subgroup of AD that represents a low percentage of AD cases with an early onset of the disease. Different APP FAD mutatio...

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Literature Corpus work
223c69f0-92c7-5fa3-9cbc-6acd4fccd2a3
DOI
10.21203/rs.3.rs-2293469/v1
Open publication

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Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activityDOI 10.21203/rs.3.rs-2293469/v1
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