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Article

The C99 domain of the amyloid precursor protein resides in the disordered membrane phase.

The Journal of biological chemistry - 1 Jan 2000

Capone Ricardo, Tiwari Ajit, Hadziselimovic Arina, Peskova Yelena, Hutchison James M, Sanders Charles R, Kenworthy Anne K

Abstract excerpt

Processing of the amyloid precursor protein (APP) via the amyloidogenic pathway is associated with the etiology of Alzheimer's disease. The cleavage of APP by β-secretase to generate the transmembrane 99-residue C-terminal fragment (C99) and subsequent processing of C99 by γ-secretase to yield amyloid-β (Aβ) peptides are essential steps in this pathway. Biochemical evidence suggests that amyloidogenic processing...

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Share to Amyloid beta-Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33839158
DOI: 10.1016/j.jbc.2021.100652
PMCID: PMC8113881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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