Article

Reciprocal Modulation Between Amyloid Precursor Protein and Synaptic Membrane Cholesterol Revealed By Live Cell Imaging

2018-05-22

Abstract excerpt

<h4>Summary</h4> The amyloid precursor protein (APP) has been extensively studied because of its association with Alzheimer’s disease (AD). However, APP distribution across different subcellular membrane compartments and its function in neurons remains unclear. We generated an APP fusion protein with a pH-sensitive green fluorescent protein at its ectodomain and a pH-insensitive blue fluorescent protein at its cy...

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Literature Corpus work: 3c530843-860f-55d2-85bb-7c84154e2a66
DOI: 10.1101/328419

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