Article

Binding of different substrate molecules at the docking site and the active site of γ-secretase can trigger toxic events in sporadic and familial Alzheimer’s disease

2022-04-13

Abstract excerpt

<h4>Significance</h4> pathogenic changes in γ-secretase activity, and its response to different drugs, can be greatly affected by changes in saturation of γ-secretase with its substrate. The molecular mechanism is unclear. <h4>Results</h4> multiscale molecular dynamics studies show that saturation of γ-secretase with its substrate can result in parallel binding of different substrate molecules at the docking sit...

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Literature Corpus work: d302119a-467a-5d45-8de3-51ef45bb4994
DOI: 10.1101/2022.04.12.487996

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Binding of different substrate molecules at the docking site and the active site of γ-secretase can trigger toxic events in sporadic and familial Alzheimer’s diseaseDOI 10.1101/2022.04.12.487996Read

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