Article

The C99 domain of the amyloid precursor protein is a disordered membrane phase-preferring protein

2020-11-25

Abstract excerpt

Processing of the amyloid precursor protein (APP) via the amyloidogenic pathway is associated with the etiology of Alzheimer’s disease. The cleavage of APP by β-secretase to generate the transmembrane 99-residue C-terminal fragment (C99) and subsequent processing of C99 by γ-secretase to yield amyloid-β (Aβ) peptides are essential steps in this pathway. Biochemical evidence suggests amyloidogenic processing of C99...

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Literature Corpus work: 93940f35-7e28-5f0e-b72b-006d89e868b6
DOI: 10.1101/2020.11.25.397893

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