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Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains

30 Oct 2024

Abstract excerpt

Parkinson's disease (PD) is a prevalent neurodegenerative disorder, and recent evidence suggests that pathogenesis may be in part mediated by inflammatory processes, the molecular and cellular architectures of which are largely unknown. To identify and characterize selectively vulnerable brain cell populations in PD, we performed single-nucleus transcriptomics and unbiased proteomics to profile the prefrontal...

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PMID: 39475571
DOI: 10.1126/scitranslmed.abo1997

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