Article

Avoiding false discoveries: Revisiting an Alzheimer’s disease snRNA-Seq dataset

2023-04-02

Abstract excerpt

Mathys et al ., conducted the first single-nucleus RNA-Seq study (snRNA-Seq) of Alzheimer’s disease (AD) 1 . The authors profiled the transcriptomes of approximately 80,000 cells from the prefrontal cortex, collected from 48 individuals – 24 of which presented with varying degrees of AD pathology. With bulk RNA-Seq, changes in gene expression across cell types can be lost, potentially masking the differentially...

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Literature Corpus work: 63042df9-1c65-5f4b-a24e-750227cfed6f
DOI: 10.1101/2023.04.01.535040

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