Article
B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation.
Frontiers in immunology - 1 Jan 2021
Green Kenneth, Wittenborn Thomas R, Fahlquist-Hagert Cecilia, Terczynska-Dyla Ewa, van Campen Nina, Jensen Lisbeth, Reinert Line, Hartmann Rune, Paludan Søren R, Degn Søren E
Abstract excerpt
Germinal centers (GCs) are induced microanatomical structures wherein B cells undergo affinity maturation to improve the quality of the antibody response. Although GCs are crucial to appropriate humoral responses to infectious challenges and vaccines, many questions remain about the molecular signals driving B cell participation in GC responses. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes...
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