Article

Single-cell analysis reveals dynamics of human B cell differentiation and identifies novel B and antibody-secreting cell intermediates

2022-10-05

Abstract excerpt

<h4>ABSTRACT</h4> Differentiation of B cells into antibody-secreting cells (ASCs) is a key process to generate protective humoral immunity. A detailed understanding of the cues controlling ASC differentiation is important to devise strategies to modulate antibody formation. Here, we dissected differentiation trajectories of human naive B cells into ASCs using single-cell RNA sequencing. By comparing transcriptome...

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Literature Corpus work: d4053bb3-d678-513d-add6-d7c12fa13769
DOI: 10.1101/2022.10.03.510595

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