Article

The germinal center antibody response in health and disease

2016-05-25

Abstract excerpt

The germinal center response is the delayed but sustained phase of the antibody response that is responsible for producing high-affinity antibodies of the IgG, IgA and/or IgE isotypes. B cells in the germinal center undergo re-iterative cycles of somatic hypermutation of immunoglobulin gene variable regions, clonal expansion, and Darwinian selection for cells expressing higher-affinity antibody variants. Alternati...

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Literature Corpus work: dbbb07bf-9fe3-5dee-927e-f5cacfe95587
DOI: 10.12688/f1000research.7717.1

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