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Article

System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation.

Frontiers in immunology - 1 Jan 2021

Verstegen Niels J M, Ubels Victor, Westerhoff Hans V, van Ham S Marieke, Barberis Matteo

Abstract excerpt

Germinal center (GC) reactions are vital to the correct functioning of the adaptive immune system, through formation of high affinity, class switched antibodies. GCs are transient anatomical structures in secondary lymphoid organs where specific B cells, after recognition of antigen and with T cell help, undergo class switching. Subsequently, B cells cycle between zones of proliferation and somatic hypermutation...

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Identifiers

PMID: 34616402
DOI: 10.3389/fimmu.2021.734282
PMCID: PMC8488341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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