Article

An epitope-enriched immunogen increases site targeting in germinal centers

2022-12-02

Abstract excerpt

<h4>ABSTRACT</h4> Antibody immunodominance is the asymmetric elicitation of responses against protein antigens. For influenza hemagglutinin (HA), antibody responses often target variable regions on HA and do not provide lasting protection. Next-generation influenza vaccines should elicit antibodies targeting conserved regions such as the receptor binding site (RBS). Understanding how presenting an epitope on a ra...

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Literature Corpus work: 942e4455-6339-5b66-a6a5-653282f23c41
DOI: 10.1101/2022.12.01.518697

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