Article
Induction of a germinal center phenotype in B cells in vitro by a Th2 cell line.
Cellular immunology - 15 Dec 1999
Morafo V, Rath S, Thomas M L, Durdik J M
Abstract excerpt
We have investigated the contribution of various stimuli for generating in vitro the changes in surface phenotype characteristic of B cells responding to a T-dependent antigen in a germinal center (GC). We show that, unlike many other stimuli such as B cell mitogens, cytokines, and surrogate antigen, alone or in combination, an alloreactive Th2 clonal line induces splenic B cells to become cell surface peanut...
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