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Article

Germinal center responses to complex antigens

26 Jun 2018

Abstract excerpt

Germinal centers (GCs) are the primary sites of antibody affinity maturation, sites where B-cell antigen-receptor (BCR) genes rapidly acquire mutations and are selected for increasing affinity for antigen. This process of hypermutation and affinity-driven selection results in the clonal expansion of B cells expressing mutated BCRs and acts to hone the antibody repertoire for greater avidity and specificity....

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PMID: 29944756
DOI: 10.1111/imr.12661

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