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A Systematic Review and Analysis of the Use of Polygenic Scores in Pharmacogenomics.

Clinical pharmacology and therapeutics - 1 Apr 2022

Johnson Danielle, Wilke MacKenzie A P, Lyle Sarah M, Kowalec Kaarina, Jorgensen Andrea, Wright Galen E B, Drögemöller Britt I

Abstract excerpt

Polygenic scores (PGSs) have emerged as promising tools for complex trait risk prediction. The application of these scores to pharmacogenomics provides new opportunities to improve the prediction of treatment outcomes. To gain insight into this area of research, we conducted a systematic review and accompanying analysis. This review uncovered 51 papers examining the use of PGSs for drug-related outcomes, with the...

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PMID: 34953075
DOI: 10.1002/cpt.2520

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