Article
Prognostic value of polygenic risk scores for adults with psychosis.
Nature medicine - 1 Sept 2021
Landi Isotta, Kaji Deepak A, Cotter Liam, Van Vleck Tielman, Belbin Gillian, Preuss Michael, Loos Ruth J F, Kenny Eimear, Glicksberg Benjamin S, Beckmann Noam D, O'Reilly Paul, Schadt Eric E, Achtyes Eric D, Buckley Peter F, Lehrer Douglas, Malaspina Dolores P, McCarroll Steven A, Rapaport Mark H, Fanous Ayman H, Pato Michele T, Pato Carlos N, Bigdeli Tim B, Nadkarni Girish N, Charney Alexander W
Abstract excerpt
Polygenic risk scores (PRS) summarize genetic liability to a disease at the individual level, and the aim is to use them as biomarkers of disease and poor outcomes in real-world clinical practice. To date, few studies have assessed the prognostic value of PRS relative to standards of care. Schizophrenia (SCZ), the archetypal psychotic illness, is an ideal test case for this because the predictive power of the SCZ...
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