Article

Exploring the Space of Tumor Phylogenies Consistent with Single-Cell Whole-Genome Sequencing Data

2026-01-23

Abstract excerpt

Tumors comprise subpopulations of cells that harbor distinct collections of somatic mutations, ranging from single-nucleotide variants (SNVs) to large-scale copy-number aberrations (CNAs). Single-cell whole-genome sequencing (scWGS) enables direct measurement of these mutations; however, inferring tumor phylogenies from scWGS data remains challenging due to ultra-low coverage (∼0.05 ×). There may be multiple ways...

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Literature Corpus work: 9f5b44fa-aef3-5107-a8dc-a5cfc2ec7e47
DOI: 10.64898/2026.01.21.700922

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