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Article

Single-cell mutation identification via phylogenetic inference

28 Nov 2018

Abstract excerpt

Reconstructing the evolution of tumors is a key aspect towards the identification of appropriate cancer therapies. The task is challenging because tumors evolve as heterogeneous cell populations. Single-cell sequencing holds the promise of resolving the heterogeneity of tumors; however, it has its own challenges including elevated error rates, allelic drop-out, and uneven coverage. Here, we develop a new approach...

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PMID: 30514897
DOI: 10.1038/s41467-018-07627-7

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