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Phertilizer: Growing a clonal tree from ultra-low coverage single-cell DNA sequencing of tumors

11 Oct 2023

Abstract excerpt

Emerging ultra-low coverage single-cell DNA sequencing (scDNA-seq) technologies have enabled high resolution evolutionary studies of copy number aberrations (CNAs) within tumors. While these sequencing technologies are well suited for identifying CNAs due to the uniformity of sequencing coverage, the sparsity of coverage poses challenges for the study of single-nucleotide variants (SNVs). In order to maximize the...

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PMID: 37819942
DOI: 10.1371/journal.pcbi.1011544

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