Article

Single-cell tumor phylogeny inference with copy-number constrained mutation losses

2019-11-26

Abstract excerpt

<h4>Motivation</h4> Single-cell DNA sequencing enables the measurement of somatic mutations in individual tumor cells, and provides data to reconstruct the evolutionary history of the tumor. Nearly all existing methods to construct phylogenetic trees from single-cell sequencing data use single-nucleotide variants (SNVs) as markers. However, most solid tumors contain copy-number aberrations (CNAs) which can overla...

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Literature Corpus work: be32c236-00ca-5004-af9c-2821619d2d9a
DOI: 10.1101/840355

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