Article

PHALCON: phylogeny-aware variant calling from large-scale single-cell panel sequencing datasets

2024-12-26

Abstract excerpt

Single-cell sequencing (SCS) enables variant detection and tumor phylogeny reconstruction for resolving intra-tumor heterogeneity (ITH), which causes drug resistance and cancer relapse. Recently emerged panel sequencing methods sequence disease-specific genes across thousands of cells, but existing variant callers and SCS-specific phylogenetic methods struggle with large-scale datasets and amplification biases in...

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Literature Corpus work: d549950d-d89d-5320-b9d9-d83d8322e196
DOI: 10.1101/2024.12.26.630385

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