Article

Pharming: Joint Clonal Tree Reconstruction of SNV and CNA Evolution from Single-cell DNA Sequencing of Tumors

2024-11-18

Abstract excerpt

Cancer arises through an evolutionary process in which somatic mutations, including single nucleotide variants (SNVs) and copy number aberrations (CNAs), drive the development of a malignant, heterogeneous tumor. Reconstructing this evolutionary history from sequencing data is critical for understanding the order in which mutations are acquired and the dynamic interplay between different types of alterations. Adva...

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Literature Corpus work: d0b78f54-8307-5d6d-8420-f1dd081a6765
DOI: 10.1101/2024.11.17.623950

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