Article

ConDoR: Tumor phylogeny inference with a copy-number constrained mutation loss model

2023-01-06

Abstract excerpt

Tumors consist of subpopulations of cells that harbor distinct collections of somatic mutations. These mutations range in scale from single nucleotide variants (SNVs) to large-scale copy-number aberrations (CNAs). While many approaches infer tumor phylogenies using SNVs as phylogenetic markers, CNAs that overlap SNVs may lead to erroneous phylogenetic inference. Specifically, an SNV may be lost in a cell due to a...

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Literature Corpus work: da103075-3986-5744-9ab4-ab0ad58029c3
DOI: 10.1101/2023.01.05.522408

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