Article

A Combinatorial Approach for Single-cell Variant Detection via Phylogenetic Inference

2019-07-05

Abstract excerpt

Single-cell sequencing provides a powerful approach for elucidating intratumor heterogeneity by resolving cell-to-cell variability. However, it also poses additional challenges including elevated error rates, allelic dropout and non-uniform coverage. A recently introduced single-cell-specific mutation detection algorithm leverages the evolutionary relationship between cells for denoising the data. However, due to...

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Literature Corpus work: 19042397-431d-5cd5-8205-e625835d5eb3
DOI: 10.1101/693960

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