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Article

SCARLET: Single-cell tumor phylogeny inference with copy-number constrained mutation losses.

Cell systems - 22 Apr 2020

Satas Gryte, Zaccaria Simone, Mon Geoffrey, Raphael Benjamin J

Abstract excerpt

A small number of somatic mutations drive the development of cancer, but all somatic mutations are markers of the evolutionary history of a tumor. Prominent methods to construct phylogenies from single-cell sequencing data use single-nucleotide variants (SNVs) as markers but fail to adequately account for copy-number aberrations (CNAs), which can overlap SNVs and result in SNV losses. Here, we introduce SCARLET,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32864481
DOI: 10.1016/j.cels.2020.04.001
PMCID: PMC7451135

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