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Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon

24 Feb 2023

Abstract excerpt

BACKGROUND: Despite the process of DNA replication being mechanistically highly conserved, the location of origins of replication (ORI) may vary from one tissue to the next, or between rounds of replication in eukaryotes, suggesting flexibility in the choice of locations to initiate replication. Lists of human ORI therefore vary widely in number and location, and there are currently no methods available to...

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PMID: 36829160
DOI: 10.1186/s12915-023-01527-z

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