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Human-like <i>APOBEC3</i> gene expression and anti-viral responses following replacement of mouse <i>Apobec3</i> with the 7-gene human <i>APOBEC3</i> locus

2024-07-30

Abstract excerpt

The seven human APOBEC3 (hA3) genes encode polynucleotide cytidine deaminases that play vital roles in restricting replication of viruses and retrotransposons. However, off-target A3 deamination of the cellular genome is a major source of somatic mutations in human cancer. The ability to study A3 biology in vivo is hindered by the fact that the solitary murine Apobec3 gene (mA3) encodes a cytoplasmic enzyme, wit...

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Literature Corpus work
9dd25862-adbc-5b1e-a604-81cda679d157
DOI
10.1101/2024.07.30.605801
Open publication

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Human-like <i>APOBEC3</i> gene expression and anti-viral responses following replacement of mouse <i>Apobec3</i> with the 7-gene human <i>APOBEC3</i> locusDOI 10.1101/2024.07.30.605801
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