Article

Human APOBEC3G prevents emergence of infectious endogenous retrovirus in mice

2018-10-31

Abstract excerpt

Endogenous retroviruses (ERV) are found throughout vertebrate genomes and failure to silence their activation can have deleterious consequences on the host. Introduction of mutations that subsequently prevent transcription of ERV loci is therefore an indispensable cell-intrinsic defense mechanism that maintains the integrity of the host genome. Abundant in vitro and in silico evidence have revealed that APOBEC3...

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Literature Corpus work: 384900b7-4551-50a7-adc5-5ce83f9bfe15
DOI: 10.1101/457937

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