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Mice Deficient in APOBEC2 and APOBEC3

29 Jul 2005

Abstract excerpt

The activation-induced deaminase/apolipoprotein B-editing catalytic subunit 1 (AID/APOBEC) family comprises four groups of proteins. Both AID, a lymphoid-specific DNA deaminase that triggers antibody diversification, and APOBEC2 (function unknown) are found in all vertebrates examined. In contrast, APOBEC1, an RNA-editing enzyme in gastrointestinal cells, and APOBEC3 are restricted to mammals. The function of...

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Identifiers

PMID: 16055735
DOI: 10.1128/mcb.25.16.7270-7277.2005

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