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Article

Apobec3 shows rapid evolution in house mouse subspecies and unusual hypermutation patterns of endogenous mouse mammary tumor viruses.

Journal of virology - 23 Oct 2025

Shaffer Esther, Boso Guney, Sadjadpour Reza, Yedavalli Venkat V S R K, Lam Oscar, Kozak Christine A

Abstract excerpt

Apobec3 (A3, apolipoprotein B editing complex 3) is a cytidine deaminase with broadly antiretroviral activity. A3 is packaged in virions and converts cytidines to uracil (C > U) in viral minus-strand DNA during reverse transcription, resulting in guanosine to adenosine (G > A) mutations in the viral plus strand. Mouse Apobec3 (mA3) mutagenizes numerous infectious retroviruses and some families of endogenous...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40956086
DOI: 10.1128/jvi.01251-25
PMCID: PMC12548423

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