Article
Acute expression of human APOBEC3B in mice results in RNA editing and lethality.
Genome biology - 24 Nov 2023
Alonso de la Vega Alicia, Temiz Nuri Alpay, Tasakis Rafail, Somogyi Kalman, Salgueiro Lorena, Zimmer Eleni, Ramos Maria, Diaz-Jimenez Alberto, Chocarro Sara, Fernández-Vaquero Mirian, Stefanovska Bojana, Reuveni Eli, Ben-David Uri, Stenzinger Albrecht, Poth Tanja, Heikenwälder Mathias, Papavasiliou Nina, Harris Reuben S, Sotillo Rocio
Abstract excerpt
BACKGROUND: RNA editing has been described as promoting genetic heterogeneity, leading to the development of multiple disorders, including cancer. The cytosine deaminase APOBEC3B is implicated in tumor evolution through DNA mutation, but whether it also functions as an RNA editing enzyme has not been studied. RESULTS: Here, we engineer a novel doxycycline-inducible mouse model of human APOBEC3B-overexpression to...
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