Article

Repair of APOBEC3G-mutated retroviral DNA <i>in vivo</i> is facilitated by the host enzyme uracil DNA glycosylase 2

2021-08-25

Abstract excerpt

Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3 (APOBEC3) proteins are critical for the control of infection by retroviruses. These proteins deaminate cytidines in negative strand DNA during reverse transcription, leading to G to A changes in coding strands. Uracil DNA glycosylase (UNG) is a host enzyme that excises uracils in genomic DNA, which the base excision repair machinery then repairs. Whether UNG...

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Literature Corpus work: c85fdd37-a4b7-52c3-b4fa-d21003dea665
DOI: 10.1101/2021.08.25.457690

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