Article
The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.
Nature communications - 21 Sept 2016
Starrett Gabriel J, Luengas Elizabeth M, McCann Jennifer L, Ebrahimi Diako, Temiz Nuri A, Love Robin P, Feng Yuqing, Adolph Madison B, Chelico Linda, Law Emily K, Carpenter Michael A, Harris Reuben S
Abstract excerpt
Cytosine mutations within TCA/T motifs are common in cancer. A likely cause is the DNA cytosine deaminase APOBEC3B (A3B). However, A3B-null breast tumours still have this mutational bias. Here we show that APOBEC3H haplotype I (A3H-I) provides a likely solution to this paradox. A3B-null tumours with this mutational bias have at least one copy of A3H-I despite little genetic linkage between these genes. Although...
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