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Article

APOBEC3A catabolism of electroporated plasmid DNA in mouse muscle.

Gene therapy - 1 Jan 2015

Kostrzak A, Henry M, Demoyen P L, Wain-Hobson S, Vartanian J-P

Abstract excerpt

The mouse is widely used as a model for DNA therapy and vaccination even though the efficiency of DNA delivery in higher mammals and humans is much less. The human APOBEC3 (A3) enzymes impact viral genomes by cytidine deamination, which introduces multiple uridine residues into single-stranded DNA, a process known as genetic editing. This initiates rapid DNA catabolism via a uracil DNA glycosylase dependent...

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PMID: 25298040
DOI: 10.1038/gt.2014.88

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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