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Article

Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA.

BMC genomics - 14 Nov 2019

Caval Vincent, Jiao Wenjuan, Berry Noémie, Khalfi Pierre, Pitré Emmanuelle, Thiers Valérie, Vartanian Jean-Pierre, Wain-Hobson Simon, Suspène Rodolphe

Abstract excerpt

BACKGROUND: APOBEC1 (A1) enzymes are cytidine deaminases involved in RNA editing. In addition to this activity, a few A1 enzymes have been shown to be active on single stranded DNA. As two human ssDNA cytidine deaminases APOBEC3A (A3A), APOBEC3B (A3B) and related enzymes across the spectrum of placental mammals have been shown to introduce somatic mutations into nuclear DNA of cancer genomes, we explored the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31726973
DOI: 10.1186/s12864-019-6216-x
PMCID: PMC6854741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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