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Different Modes of Retrovirus Restriction by Human APOBEC3A and APOBEC3G In Vivo

22 May 2014

Abstract excerpt

The apolipoprotein B editing complex 3 (A3) cytidine deaminases are among the most highly evolutionarily selected retroviral restriction factors, both in terms of gene copy number and sequence diversity. Primate genomes encode seven A3 genes, and while A3F and 3G are widely recognized as important in the restriction of HIV, the role of the other genes, particularly A3A, is not as clear. Indeed, since human cells...

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PMID: 24851906
DOI: 10.1371/journal.ppat.1004145

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