Article

Using Multi-Ancestry Polygenic Risk Scores for Coronary Artery Disease as Risk Enhancers for a 10 Year Cardiovascular Risk Assessment Tool

2023-04-27

Abstract excerpt

Clinical implementation of new prediction models requires evaluation of their validity and utility in a broad range of intended use populations. Here we outline the development and validation of multiple ancestry-specific Polygenic Risk Scores (PRSs) for Coronary Artery Disease (CAD) using a dataset comprising 29,389 individuals from multiple cohorts and diverse genetic ancestry groups. We leverage summary statist...

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Literature Corpus work: 9d8940d5-5412-5dc6-bb9c-448936fd7b79
DOI: 10.21203/rs.3.rs-2840714/v1

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