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Article

Precision Medicine in Cardiovascular Disease Prevention: Clinical Validation of Multi-Ancestry Polygenic Risk Scores in a U.S. Cohort.

Nutrients - 6 Mar 2025

Ponikowska Małgorzata, Di Domenico Paolo, Bolli Alessandro, Busby George Bartholomew, Perez Emma, Bottà Giordano

Abstract excerpt

BACKGROUND: Polygenic risk score (PRS) quantifies the cumulative effects of common genetic variants across the genome, including both coding and non-coding regions, to predict the risk of developing common diseases. In cardiovascular medicine, PRS enhances risk stratification beyond traditional clinical risk factors, offering a precision medicine approach to coronary artery disease (CAD) prevention. This study...

Read the complete abstract on PubMed

Topics

Humans
Precision Medicine
Cardiovascular Diseases
Risk Assessment
Female
United States

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Middle Aged

Multifactorial Inheritance

Genetic Predisposition to Disease

Cohort Studies

Risk Factors

Aged

Coronary Artery Disease

Genetic Risk Score

Source

Open in PubMed Open full text

Identifiers

PMID: 40077796
DOI: 10.3390/nu17050926
PMCID: PMC11901995

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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