Validation of an Integrated Risk Tool, Including Polygenic Risk Score, for Atherosclerotic Cardiovascular Disease in Multiple Ethnicities and Ancestries.

doi:10.1016/j.amjcard.2021.02.032

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Article

Validation of an Integrated Risk Tool, Including Polygenic Risk Score, for Atherosclerotic Cardiovascular Disease in Multiple Ethnicities and Ancestries.

The American journal of cardiology - 1 Jun 2021

Weale Michael E, Riveros-Mckay Fernando, Selzam Saskia, Seth Priyanka, Moore Rachel, Tarran William A, Gradovich Eva, Giner-Delgado Carla, Palmer Duncan, Wells Daniel, Saffari Ayden, Sivley R Michael, Lachapelle Alexander S, Wand Hannah, Clarke Shoa L, Knowles Joshua W, O'Sullivan Jack W, Ashley Euan A, McVean Gil, Plagnol Vincent, Donnelly Peter

Abstract excerpt

The American College of Cardiology / American Heart Association pooled cohort equations tool (ASCVD-PCE) is currently recommended to assess 10-year risk for atherosclerotic cardiovascular disease (ASCVD). ASCVD-PCE does not currently include genetic risk factors. Polygenic risk scores (PRSs) have been shown to offer a powerful new approach to measuring genetic risk for common diseases, including ASCVD, and to...

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PMID: 33675770
DOI: 10.1016/j.amjcard.2021.02.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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