Article

Prediction of incident coronary artery disease in individuals with zero coronary artery calcium using a novel multi-ancestry, label-free polygenic risk score framework

2026-03-04

Abstract excerpt

<h4>Background</h4> A coronary artery calcium (CAC) score of 0 is widely considered to indicate low short- to intermediate-term risk for coronary artery disease (CAD) and is frequently used to defer lipid-lowering therapy. However, a subset of individuals with CAC=0 still experience events, highlighting residual risk not captured by imaging alone. Polygenic risk scores (PRS) quantify lifelong inherited susceptibi...

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Literature Corpus work: d7164499-86c7-507e-b951-d5d5aa109561
DOI: 10.64898/2026.03.02.26347474

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