Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization.

doi:10.1161/CIRCGEN.123.004272

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Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization.

Circulation. Genomic and precision medicine - 1 Jun 2024

Smith Johanna L, Tcheandjieu Catherine, Dikilitas Ozan, Iyer Kruthika, Miyazawa Kazuo, Hilliard Austin, Lynch Julie, Rotter Jerome I, Chen Yii-Der Ida, Sheu Wayne Huey-Herng, Chang Kyong-Mi, Kanoni Stavroula, Tsao Philip S, Ito Kaoru, Kosel Matthew, Clarke Shoa L, Schaid Daniel J, Assimes Themistocles L, Kullo Iftikhar J

Abstract excerpt

BACKGROUND: Predictive performance of polygenic risk scores (PRS) varies across populations. To facilitate equitable clinical use, we developed PRS for coronary heart disease (CHD; PRSCHD) for 5 genetic ancestry groups. METHODS: We derived ancestry-specific and multi-ancestry PRSCHD based on pruning and thresholding (PRSPT) and ancestry-based continuous shrinkage priors (PRSCSx) applied to summary statistics from...

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Identifiers

PMID: 38380516
DOI: 10.1161/CIRCGEN.123.004272
PMCID: PMC11372723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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